Research and Development
PWTTR (Pulse Wave Transit Time Ratio)
“The study demonstrates that the aorta-to-arm pulse wave transit time (PWTT) ratio is a more effective and reliable predictor of coronary artery disease (CAD) and stroke compared to the conventional carotid-femoral pulse wave velocity (cfPWV). The primary advantage of the PWTT ratio is that it eliminates the need for imprecise and non-standardized measurements of pulse wave travel length, which often lead to significant variances in cfPWV results. By using a ratio of transit times, this method provides a more accurate assessment of the arterial stiffness gradient and shows a stronger correlation with cardiovascular events, suggesting its potential as a superior clinical tool for risk assessment.” – Young-Boum Lee, Sang-Wuk Jeong, Moo-Yong Rhee, Chae-Hun Leem (2016), Aorta-to-arm pulse wave transit time ratio: Better prediction of coronary artery disease and stroke than pulse wave velocity, International Journal of Cardiology 204, P1-3
AI assisted research on cardiovascular function
“This research aims to establish a framework for interpreting cardiovascular functions by integrating vascular network models with AI representation learning. The goal is to accurately estimate central physiological metrics from peripheral pulse wave data and to provide a foundation for personalized cardiovascular digital twin models through a physiologically constrained AI approach. It will pioneer AI framework that integrates physiological principles with graph-based representation learning, moving beyond simple data-driven predictions to provide physiologically interpretable insights.”
AI diagnostics solutions
“We will continue to integrate the outcomes from the researches on cardiovascular functions into our diagnostics hardware to advance accuracy and coverage of diagnostics. These advancements will expand healthcare frontiers in;
Non-invasive diagnostics: The ability to estimate core cardiovascular metrics from peripheral sites (like the wrists) offers a pain-free, non-invasive alternative to clinical catheterization, making continuous monitoring feasible for high-risk patients.
Early detection & Prevention: Providing precise indicators such as arterial stiffness and cardiac ejection fraction enables early risk assessment for ischemic heart disease and stroke, potentially reducing mortality rates.”